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Page 1
Pyogenic bacterial infections in humans with MyD88 deficiency.
von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Aróstegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yagüe J, Antón J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Maródi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL. von Bernuth H, et al. Science. 2008 Aug 1;321(5889):691-6. doi: 10.1126/science.1158298. Science. 2008. PMID: 18669862 Free PMC article.
MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. ...Their clinical status improved with age, but not due to any cellular leakiness in MyD88 deficiency. The MyD88-dependent TLRs …
MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. ...Their …
MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization.
Zhang J, Liu Y, Chen H, Yuan Q, Wang J, Niu M, Hou L, Gu J, Zhang J. Zhang J, et al. Cell Death Dis. 2022 Apr 28;13(4):411. doi: 10.1038/s41419-022-04802-z. Cell Death Dis. 2022. PMID: 35484116 Free PMC article.
Here, we used a CCl(4)-induced mouse fibrosis model in which MyD88 was selectively depleted in qHSCs (GFAP(MyD88-/-) mice) or aHSCs (alpha-SMA(MyD88-/-) mice). MyD88 deficiency in qHSCs or aHSCs attenuated liver fibrosis in mice and inhibited al …
Here, we used a CCl(4)-induced mouse fibrosis model in which MyD88 was selectively depleted in qHSCs (GFAP(MyD88-/-) mice) or …
HMGB1-Mediated Neutrophil Extracellular Trap Formation Exacerbates Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury.
Zhan Y, Ling Y, Deng Q, Qiu Y, Shen J, Lai H, Chen Z, Huang C, Liang L, Li X, Wu J, Huang W, Wen S. Zhan Y, et al. J Immunol. 2022 Feb 15;208(4):968-978. doi: 10.4049/jimmunol.2100593. Epub 2022 Jan 21. J Immunol. 2022. PMID: 35063996
Moreover, recombinant human HMGB1 administration further drives NETs and concurrent tissue toxic injury, which in turn can be reversed by neutrophil deletion via anti-Ly6G Ab i.p. injection. Furthermore, global MyD88 deficiency regulated NET formation and alleviated …
Moreover, recombinant human HMGB1 administration further drives NETs and concurrent tissue toxic injury, which in turn can be reversed by ne …
MyD88 deficiency results in both cognitive and motor impairments in mice.
Drouin-Ouellet J, LeBel M, Filali M, Cicchetti F. Drouin-Ouellet J, et al. Brain Behav Immun. 2012 Aug;26(6):880-5. doi: 10.1016/j.bbi.2012.02.007. Epub 2012 Feb 28. Brain Behav Immun. 2012. PMID: 22401992
To understand the full implication of this pathway, we tested MyD88(-/-) mice for both motor and cognitive functions in normal conditions. ...Our findings shed light on behavioral alterations that are associated with the deletion of the MyD88 protein in physiologica …
To understand the full implication of this pathway, we tested MyD88(-/-) mice for both motor and cognitive functions in normal condit …
ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells.
Griesenauer B, Jiang H, Yang J, Zhang J, Ramadan AM, Egbosiuba J, Campa K, Paczesny S. Griesenauer B, et al. J Immunol. 2019 May 15;202(10):3053-3064. doi: 10.4049/jimmunol.1800447. Epub 2019 Apr 12. J Immunol. 2019. PMID: 30979817 Free PMC article.
Plasma levels of soluble membrane-bound ST2 (ST2) are elevated in human and murine aGVHD and correlated to type 1 T cells response. ST2 signals through the adapter protein MyD88. The role of MyD88 in T cells during aGVHD has yet to be elucidated. ...This protection …
Plasma levels of soluble membrane-bound ST2 (ST2) are elevated in human and murine aGVHD and correlated to type 1 T cells response. ST2 sign …
MyD88 deficiency enhances acquisition and transmission of Borrelia burgdorferi by Ixodes scapularis ticks.
Bockenstedt LK, Liu N, Schwartz I, Fish D. Bockenstedt LK, et al. Infect Immun. 2006 Apr;74(4):2154-60. doi: 10.1128/IAI.74.4.2154-2160.2006. Infect Immun. 2006. PMID: 16552045 Free PMC article.
Innate immune cells recognize B. burgdorferi by Toll-like receptors (TLRs) that use the intracellular molecule MyD88 to mediate effector functions. To determine whether impaired TLR signaling enhances Ixodes scapularis acquisition of B. burgdorferi, we fed nymphs on wild-t …
Innate immune cells recognize B. burgdorferi by Toll-like receptors (TLRs) that use the intracellular molecule MyD88 to mediate effec …
Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans.
von Bernuth H, Picard C, Puel A, Casanova JL. von Bernuth H, et al. Eur J Immunol. 2012 Dec;42(12):3126-35. doi: 10.1002/eji.201242683. Eur J Immunol. 2012. PMID: 23255009 Free PMC article. Review.
Most Toll-like-receptors (TLRs) and interleukin-1 receptors (IL-1Rs) signal via myeloid differentiation primary response 88 (MyD88) and interleukin-1 receptor-associated kinase 4 (IRAK-4). The combined roles of these two receptor families in the course of experimental infe …
Most Toll-like-receptors (TLRs) and interleukin-1 receptors (IL-1Rs) signal via myeloid differentiation primary response 88 (MyD88) a …
MyD88 Deficiency Protects Against Dry Eye-Induced Damage.
Reins RY, Lema C, Courson J, Kunnen CME, Redfern RL. Reins RY, et al. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2967-2976. doi: 10.1167/iovs.17-23397. Invest Ophthalmol Vis Sci. 2018. PMID: 30025110 Free PMC article.
Similarly, MyD88-/- mice did not have increased corneal MMP-2, 3, or 8 concentrations, as seen with WT mice. MyD88-deficiency also resulted in decreased corneal cytokine levels. ...
Similarly, MyD88-/- mice did not have increased corneal MMP-2, 3, or 8 concentrations, as seen with WT mice. MyD88-deficien …
MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis.
Yang DJ, Wang XD, Fu XY, Lu HM, Zhou ZG, Liu Y. Yang DJ, et al. Ann Transl Med. 2022 Nov;10(22):1214. doi: 10.21037/atm-22-5134. Ann Transl Med. 2022. PMID: 36544673 Free PMC article.
Additionally, Nec-1 treatment significantly reduced necrosis in the MyD88(-/-) mice. CONCLUSIONS: The deletion of MyD88 inhibited the TLR4/MyD88-dependent pathway mediated protective immune defense response and enhanced TLR4/MyD88-independent TRIF path …
Additionally, Nec-1 treatment significantly reduced necrosis in the MyD88(-/-) mice. CONCLUSIONS: The deletion of MyD88 inhibi …
163 results